赵黎明
生物工程专业：博士生导师/硕士生导师
生物化工专业：博士生导师
食品科学与工程专业：硕士生导师
生物与医药专业（生物工程领域）：博士生导师/硕士生导师
Liming Zhao
Professor, Ph.D.
School of Biotechnology, East China University of Science and Technology, China
Liming Zhao is professor of the department of food science and technology at East China University of Science and Technology (ECUST). He is a PI of the State Key Laboratory of Bioreactor Engineering, and the Director of the Key Laboratory of Biobased Material Engineering of China Light Industry. He has worked on food science and technology in industryfor eight years, after obtaining his PhD in Food Science at Jiangnan University, he joined ECUST and was invited as a visiting professor at University of California Davis.
His research focuses on food bioengineering, especially on the preparation, separation and application of functional oligosaccharides. He has special interest in: 1) chitin and its derivatives; 2) the technology and equipment of membrane and chromatography separation; 3) bio-manufacturing of functional oligosaccharides; 4) biobased materials. He has published more than 140 original scientific papers in peer-reviewed journals, he also published his monographs of Oligosaccharides of Chitin and Chitosan: Bio-manufacture and Applications (Springer Nature) in Sept. 2019, andthe Application of Membrane Technology in Food and Fermentation Industries in July 2011.
个人介绍：
博士、教授、博士生导师，国家高层次人才，国家重点研发计划项目首席科学家，海军军医大学第二附属医院兼职特聘PI。现任必赢电子游戏官网科研院院长、国家技术转移中心主任，中国轻工业生物基材料工程重点实验室主任，发酵工业分离提取技术研发中心主任，必赢电子游戏官网—上海长征医院特医食品联合研究中心主任。中国食品科学技术学会食品添加剂分会理事长、休闲食品加工技术分会副理事长、青年工作委员会副主任委员；中国生物发酵产业协会理事、益生制品分会副理事长；上海食品学会常务理事。Food Bioengineering主编，《化学试剂》副主编，Food Science & Nutrition、Bioresources and Bioprocessing、《中国食品学报》、《食品工业科技》、《食品科学》、《生物技术进展》、《中国酿造》、《食品安全质量检测学报》等国际国内学术期刊编委。
分别于无锡轻工大学、江南大学（原无锡轻工大学）食品学院获得食品科学与工程专业工学学士（1999.6）、硕士（2001.12）、博士（2009.12）学位。2002年5月至2010年5月，兼任上海市高校毕业生就业指导中心（现上海市学生事务中心）流动党支部书记。2002.3~2004.10年，任职于上海生远食品科技有限公司。2005年1月至2009年1月，任职于凯能高科技工程(上海)有限公司工业流体事业部。2009年1月出任江苏欣瑞食品科技发展有限公司总经理。2010年4月调入必赢电子游戏官网任教，2011年9月晋升副教授，2013年3月至2014年3月在美国加州大学戴维斯分校农业与生物工程系做访问学者，2015年9月破格晋升教授。2016年3月至2019年11月任必赢电子游戏官网副院长；2019年11月至2021年5月任必赢电子游戏官网党委书记；2021年5月任必赢电子游戏官网科学技术发展研究院院长。
近年来主持多项国家级项目、课题和省部级项目，承担了20余项企业横向课题研发和产业化推广工作，具有丰富的工程实践经验。以第一完成人获得省部级科技奖励6项；申请发明专利65件、授权中国发明专利45件、美国发明专利1件；发表学术论文150余篇；出版中、英文学术专著3部；主编教材2部。荣获上海市优秀学术/技术带头人、上海市曙光学者、“十三五”轻工行业科技创新先进个人、中国生物发酵行业30年协同创新奖（个人）、伦世仪教育基金杰出青年学者、宝钢优秀教师、中国产学研合作创新奖（个人）、中国食品科学技术学会科技创新奖－杰出青年奖等荣誉。
研究方向：
基于分离提取技术的食品药品及材料工程。
主要研究兴趣：
1, 糖生物工程（功能碳水化合物的绿色生物制造、分离纯化及功能评价）；
2, 分离工程（膜和色谱分离技术及其在糖工程、生物制造中的应用）；
3, 生物基材料工程（新型生物基材料开发、纳米生物基材料及其在食品医药应用）；
4，特殊医学用途全营养食品、发酵食品开发。
近年主持或参加的国家级科研项目或基金：
1，主持国家重点研发计划项目：（2022YFC2104500）。
2，承担国家重点研发计划课题：水产活性组分高精度分离提取装备与稳态化技术研发（2019YFD0901805）(已结题)。
3，主持国家重点研发计划课题：低成本乳酸、丙交酯和聚乳酸制备关键技术及产业化研究（2017YFB0309302）(已结题)。
4，主持国家高技术研究发展计划（863）课题《利用生物基原料生产绿色尼龙聚丁内酰胺》（2014AA021202）(已结题)。
5，主持工信部绿色制造系统集成项目：氨基葡萄糖生产绿色关键技术开发与系统集成项目(已结题)。
6，主持国家自然科学基金项目：甲壳素加工废水纳滤传质机理/膜分离特性和污染机理研究(已结题)。
7，主持国家自然科学基金项目：纳滤分离中单糖分子结构、极性和计算分子直径对分离和传质特性的影响和机理研究(已结题)。
8，主持国家高技术研究发展计划（863）课题《高效分离纯化介质开发及应用》子课题《人用疫苗分离纯化技术及装备开发》（已结题）。
教学：
1，《食品工程原理》，本科专业核心课程，上海市重点课程、上海市一流课程；
2，《生物分离工程》，本科专业核心课程，国家精品课程；
3，《食品工厂设计》，本科专业必修课程；
4，《食品过程工程》，研究生学位必修课程
代表性论文（*通讯作者,2019-）：
1. Xingxing Zhang, Lujie Liu, Chunyue Zhang, Yuechao Zhu, Hefei Zhao, Liming Zhao*, Adsorption mechanisms of alginate oligosaccharides with specific degree of polymerizations on a novel ion-exchange resin: experiments and simulations, Chemical Engineering Journal,460, 2023, 141717
2. Yanan Cui#, Chen Deng#, Liqiang Fan, Yongjun Qiu, Liming Zhao *，Progress in the biosynthesis of bio-based PET and PEF polyester monomers，Green Chemistry，2023
3. Chen Deng, Mengxuan Zhao, Qiong Zhao，Liming Zhao*，Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides，Carbohydrate Polymers，300（2023）, 120254.
4. Difan Qian#, Chunyue Zhang#, Chen Deng, Mian Zhou, Liqiang Fan*, Liming Zhao*. De novo biosynthesis of 2’-fucosyllactose in engineered Pichia pastoris. Biotechnology Letter, 45(2023):521–536.
5. Yanying Hou, Lujie Liu, Qiaole He, Di Zhang, Jiayang Jin, Banghe Jiang, Liming Zhao*. Adsorption behaviors and kinetics studies 1 of chitooligosaccharides with specific degree of polymerization on a novel ion-exchange resin. Chemical Engineering Journal, 430 (2022) 132630.
6. Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang*, Liming Zhao*, Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291. Carbohydrate Polymers.291 (2022) 119619
7. Xiaoguo Ji, Liangliang Zhu, Kunlin Chang, Ran Zhang, Yijia Chen, Hao Yin, Jiayang Jin*, Liming Zhao*. Chitooligosaccahrides: digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro. Carbohydrate Polymers,275 (2022) 118716
8. Mengyao Zhao, Boya Zhang, Linlin Deng, Liming Zhao*.Acrylamide Induces Neurotoxicity in SH‑SY5Y Cells via NLRP3‑mediated Pyroptosis. Molecular Neurobiology.2022
9. Yajing Zhang, Zhili Cai, Yibing Wang, Jia Liu, Tao Chen*, and Liming Zhao*. Effect of sequence distribution on the non-isothermal crystallization of copolyamide 4/6. Journal of Materials Science. 57 (2022):17883–17901
10. Zhang Di, Nie Rong, Zhang Chunyue, Wang Yibing, Wang Li, Chen Tao* & Zhao Liming*. Characterization of biodegradable food packaging films prepared with polyamide 4: Influence of molecular weight and environmental humidity. Food Bioengineering, (2022) 1–13.
11. Yanying Hou, Lujie Liu , Xingxing Zhang, Yuechao Zhu, Yongjun Qiu, Liming Zhao*, Adsorption differences and mechanism of chitooligosaccharides with specific degree of polymerization on macroporous resins with different functional groups. Journal of Industrial and Engineering Chemistry .115 (2022) 416–429
12. Jiangshan You#, Mengyao Zhao#, Shumin Chen, Lihua Jiang, Shuhong Gao, Hao Yin* and Liming Zhao*, Effect of chitooligosaccharides with a specifc degree of polymerization on multiple targets in T2DM mice. Bioresources and Bioprocessing. (2022) 9:94
13. Ran Zhang, Qiong Zhao, Zhenwei Yi, Kaihang Zhang, Jinqi Shi, Liangliang Zhu, Yijia Chen, Jiayang Jin*, Liming Zhao*, Chitin oligosaccharides for the food industry: production and applications. Systems Microbiology and Biomanufacturing.2022
14. Mai Chen, Jiayang Jin, Xiaoguo Ji, Kunlin Chang, Juan Li, Liming Zhao*. Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats. Bioresources and Bioprocessing.(2022) 9:13
15. Xue Zhang, Chunyue Zhang, Mian Zhou, Quanming Xia, Liqiang Fan, Liming Zhao*. Enhanced bioproduction of chitin in engineered Pichia pastoris. Food Bioscience. 47 (2022) 101606
16. Yanqiong Liu，Chunyue Zhang，Lujie Liu，Xingxing Zhang，Yanying Hou, Liming Zhao*. Characterization of Chitin-Glucan Complex of Ganoderma lucidum Extract and Its Application as Hemostatic Hydrogel. Waste and Biomass Valorization (2022).
17. Mengfeng Gao, Qiaole He, Huizhong Dong, Jiale Wang, Junfeng Shi, Chuanqi Xie, Lo Yangming Martin, Liming Zhao*. Identification of the coupled fouling mechanism involved in microfiltration of tobacco extracts liquid by multistage Hermia model. Journal of food process engineering (2022).
18. Wang Shumin, Ji Xiaoguo, Chen Shumin, Zhang Chunyue, Wang Yibin, Lin Haodong*, Zhao Liming*. Study of double bonded carboxymethyl chitosan/cysteamine-modified chondroitin sulfate composite dressing for hemostatic application. European Polymer Journal,(2021)110875
19. Xin Shen,Xinyi Liang, Xiaoguo Ji, Jiangshan You, Xinye Zhuang, Yudong Song,Hao Yin, Mengyao Zhao* and Liming Zhao*. CD36 and DGAT2 facilitate the lipid-loweringeffect of chitooligosaccharides via fatty acidintake and triglyceride synthesis signaling.Food Functional,2021,12:8681-8693
20. Mengyao Zhao，Linlin Deng，Xiaoxuan Lu，Liqiang Fan，Yang Zhu，Liming Zhao*. The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. Environmental Science and Pollution Research, (2022) 29:41151–41167；
21. Linlin Deng, Mengyao Zhao*, Yanan Cui, Quanming Xia, Lihua Jiang, Hao Yin & Liming Zhao*. Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells, Drug and Chemical Toxicology, (2021):DOI: 10.1080/01480545.2021.1979030
22. Ling Xie, Jun Yi, Yongjia Song, Mengyao Zhao, Liqiang Fan*, Liming Zhao*. Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3β/ β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231. Food and Chemical Toxicology, 2021, (157):112574
23. Qu Tianle, Zhang Chunyue, Qin Zhen, Fan Liqiang*, Jiang Lihua* and Zhao Liming*. A Novel GH Family 20 β-N-acetylhexosaminidase With Both Chitosanase and Chitinase Activity From Aspergillus oryzae. Frontiers in Molecular Biosciences (Front. Mol. Biosci). (2021) 8:684086
24. Xiao-Guo Ji, Kun-Lin Chang, Mai Chen, Liang-Liang Zhu, Arwa Osman, Hao Yin*, Li-Ming Zhao*. In vitro fermentation of chitooligosaccharides and their effects on human fecal microbial community structure and metabolites, LWT - Food Science and Technology, 144 (2021) 111224
25. Mengyao Zhao, Shumin Chen, Xiaoguo Ji, Xin Shen, Jiangshan You, Xinyi Liang, Hao Yin*, Liming Zhao*. Nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease, Pharmacological Research, 166 (2021) 105517
26. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin*, Liming Zhao*. Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease, Journal of Functional Foods, 77 (2021) 104333
27. Chunfeng Zhu, Mengyao Zhao*, Liqiang Fan, Xuni Cao, Quanming Xia, Jiachun Zhou, Hao Yinand Liming Zhao*.Chitopentaose inhibits hepatocellularcarcinoma by inducing mitochondrialmediated apoptosis and suppressing protectiveautophagy. Bioresources and Bioprocessing. (2021) 8:4
28. Yani Wang, Zhen Qin, Liqiang Fan, Liming Zhao*. Structure–function analysis of Gynuella sunshinyii chitosanase uncovers the mechanism of substrate binding in GH family 46 members. International Journal of Biological Macromolecules. 165 (2020) 2038–2048
29. Xiaochao Hu#, Shumin Chen#, Hao Yin, QiWang, Yourong Duan, Lihua Jiang*, Liming Zhao*，Chitooligosaccharides-modified PLGA nanoparticles enhance the antitumor efficacy of AZD9291 (Osimertinib) by promoting apoptosis. International Journal of Biological Macromolecules.162 (2020) 262–272
30. Qiao-Le He, Eric von Lieres, Zhaoxi Sun, Liming Zhao*，Model-based process design of a ternary protein separation using multi-step gradient ion-exchange SMB chromatography，Computers and Chemical Engineering，138 (2020) 106851
31. Qiao-Le He, Liming Zhao*，Bayesian inference based process design and uncertainty analysis of simulated moving bed chromatographic systems，Separation and Purification Technology，246 (2020) 116856
32. Sa Luo, Zhen Qin*, Qiming Chen, Liqiang Fan, Lihua Jiang, Liming Zhao* ,High level production of a Bacillusamlyoliquefaciens chitosanase in Pichia pastoris suitable for chitooligosaccharides preparation, International Journal of Biological Macromolecules, 149 (2020) :1034–1041
33. Jiayi Chen, Qiming Chen, Chuanqi Xie, Waheed Ahmad, Lihua Jiang, Hongfang Ji, Liming Zhao*. Effects of simulated gastric and intestinal digestion on chitooligosaccharides in two in vitro models. International Journal of Food Science & Technology. 2020, 55, 1881–1890
34. Mengyao Zhao, Liming Gu, Yun Li, Shumin Chen, Jiangshan You, Liqiang Fan, Yudong Wang, Liming Zhao*. Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways. Carbohydrate Polymers. 2019, 224：115171
35. Zhen Qin#, Si Lin#, Yongjun Qiu, Qiming Chen, Yin Zhang, Jiachun Zhou, Liming Zhao*. One-step immobilization-purification of enzymes by carbohydrate-binding module family 56 tag fusion[J]. Food Chemistry, 2019, 299(30):125037.
36. Si Lin#, Zhen Qin#, Qiming Chen, Liqiang Fan, Jiachun Zhou, Liming Zhao*. Efficient immobilization of bacterial GH family 46 chitosanase by carbohydrate-binding module fusion for the controllable preparation of chitooligosaccharides[J]. Journal of Agricultural and Food Chemistry, 2019, 67(24): 6847-6855.
37. Jun Lu#, Qiming Chen#, Bolin Pan, Zhen Qin, Liqiang Fan, Quanming Xia, Liming Zhao*. Efficient inhibition of Cronobacter biofilms by chitooligosaccharides of specific molecular weight[J]. World Journal of Microbiology and Biotechnology, 2019, 35(6): 87.
38. Qiming Chen, Lu Jun, Yongjun Qiu, Liming Zhao*. Bioinformatics-based mining of novel gene targets for identification of Cronobacter turicensis using PCR[J]. Journal of Dairy Science, 2019, 102(7): 6023-6026.
39. Sijing Jiang, Liqiang Fan*, Mengyao Zhao, Yongjun Qiu, Liming Zhao*. Enhanced Low Molecular Weight Poly-γ-Glutamic Acid Production in Recombinant Bacillus subtilis 1A751 with Zinc Ion[J]. Applied Biochemistry and Biotechnology, 2019,189:411–423
40. Ping Chen, Mengyao Zhao, Qiming Chen, Liqiang Fan, Feng Gao, and Liming Zhao*，Absorption Characteristics of Chitobiose and Chitopentaose in the Human Intestinal Cell Line Caco-2 and Everted Gut Sacs，Journal of Agricultural and Food Chemistry ，2019 ，67 (16)：4513-4523.
41. Mengyao Zhao, Xin Shen, Xiaodan Li, Baoli Chen, Liqiang Fan, Quanming Xia, Liming Zhao*，Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)，Journal of Functional Foods, 57 (2019):7–18
42. Yang Zhang, Liqiang Fan, Mengyao Zhao, Qiming Chen, Zhen Qin, Zhihang Feng, Toru Fujiwara, Liming Zhao*. Chitooligosaccharide plays essential roles in regulating proline metabolism and cold stress tolerance in rice seedlings[J]. Acta Physiologiae Plantarum, 2019, 41(6): 77.
43. 蔡智立, 张雅敬, 辛瑞杰, 邱勇隽, 陈涛, 蒋丽华, 赵黎明*. LiCl 对聚丁内酰胺的热塑改性研究 [J]. 功能高分子学报，2022，35（6）：1-6.
44. 张媛婷, 明远, 陈涛*, 赵黎明*，邱勇隽. 聚乳酸/聚丁内酰胺电纺核-壳结构纤维的制备及性能 [J]. 功能高分子学报，2022，35（2）：137-145
45. 曾贝迪，陈涛*，赵黎明*．聚丁内酰胺/壳聚糖电纺纳米蛛网复合纤维膜的制备及性能．功能高分子学报. 10.14133/j.cnki.1008-9357.20210603001
46. 刘洋,张洋,范立强,赵梦瑶,赵黎明*. N-乙酰氨基葡萄糖对水稻的抗寒作用研究. 南方农业学报. 2021，52（6）:1576-1586
47. 马冰清,张忠,吴迪,范立强,张春月,周峰,杨焱*,赵黎明*.香菇菌糠高温高压－复合酶降解工艺优化及提取物的生物活性.食用菌学报.2021,28(04):27-38
48. 郑安娜,赵梦瑶,游江珊,潘小旭,赵黎明*.壳三糖胍盐酸盐对胰岛素抵抗细胞模型的改善作用．食品工业科技.2021,42(19):350-356.
49. 周卫强,李娟,沈雪梅,彭超,陈博,晏礼明,赵黎明*,李义,佟毅.基于紫外检测器的壳寡糖色谱分析与比较.理化检验(化学分册). 2021,57(08):698-702
50. 张春月，金佳杨，邱勇隽，范立强，赵黎明*. 传统与未来的碰撞：食品发酵工程技术与应用进展. 生物技术进展, 2021, 11(4):418-429
51. 陈靓，刘佳，王乐军，陈涛，陈启明，赵黎明*．聚丁内酰胺的热性能改性．高分子材料科学与工程，2021,37(2):1-6.
52. 张迪，张紫薇，李春蕊，刘佳，陈涛，赵黎明*．聚丁内酰胺的生物降解性研究进展．包装工程. 2021,42(13):136-142
53. 谢玲，益钧，宋永佳，李卓渝，范立强*，赵黎明*．基于网络药理学探究EGCG干预MDA-MB-231 细胞的潜在分子机制．必赢电子游戏官网学报(自然科学版). Doi：10.14135/j.cnki.1006-3080.20201126003
54. 马佳菲,秦臻,范立强,赵黎明*，蒋丽华*. Cyclobacterium qasimii脱乙酰酶的异源表达及酶学性质[J]. 食品科学技术学报,2020, 38(6):39-46.
55. 沈欣，赵梦瑶，邱勇隽，夏泉鸣，赵黎明*，壳寡糖对体外诱导的非酒精性脂肪肝细胞模型的降脂机理研究，食品科学技术学报，2020,38(5):41-47．
56. 张添添，陈启明，赵黎明*，姜舒文，陈涛，生物基聚丁内酰胺肠衣膜的性能分析，食品科学，2021, 42（03）：236-242
57. 马佳菲,秦臻,范立强,赵黎明*，蒋丽华*. Cyclobacterium qasimii脱乙酰酶的异源表达及酶学性质[J]. 食品科学技术学报,2020, 38(6):39-46.
58. 沈欣，赵梦瑶，邱勇隽，夏泉鸣，赵黎明*，壳寡糖对体外诱导的非酒精性脂肪肝细胞模型的降脂机理研究，食品科学技术学报，2020,38(5):41-47．
59. 张添添，陈启明，赵黎明*，姜舒文，陈涛，生物基聚丁内酰胺肠衣膜的性能分析，食品科学，20200303
60. 周卫强，沈雪梅，彭超，陈博，卢宗梅，周勇，李义，赵黎明*，佟毅，单一聚合度壳寡糖色谱分离技术的应用，化学分析计量，2020，29(4): 135–139.
61. 陈倩倩，邱勇隽，夏泉鸣，秦臻，赵黎明*．特定聚合度区间壳寡糖的膜分离制备技术[J/OL]．食品工业科技.20190625
62. 陈宝莉，秦臻，赵黎明*，粪肠球菌β-N-乙酰氨基葡萄糖苷酶基因的克隆表达及酶学性质表征. 生物技术进展. 2019,9 (3):296-302
63. 陈宝莉，秦臻，赵黎明*．解淀粉芽孢杆菌β-N-乙酰氨基葡萄糖苷酶的克隆表达及酶学表征[J/OL]．食品科学. 2020，41（8）：123-129
64. 李允，秦臻，张崟，陈启明，邱勇隽，赵黎明*．酶膜耦合法制备高聚合度壳寡糖[J/OL]．食品工业科技. 20190505
65. 吴德，唐亮琛，唐颂超，钱军，魏杰*，赵黎明*，生物基丁内酰胺及聚丁内酰胺的合成及性能，功能高分子学报．2019,32(1):110-116
发明专利：
1，赵黎明等，Method for preparing biobased nylon: polyactam，US10308764B2
2，赵黎明等，一种氨糖的电场和流场耦合调控纳滤分离方法，ZL201510273840X
3，赵黎明等，一种低温壳聚糖酶及其编码基因与应用，ZL2017101774291
4，赵黎明等，一种氨基葡萄糖合成甲壳素及其衍生物的方法，ZL201510114679.1
出版专著：
1, 主编：《生物基可降解材料的研究与应用》，上海科学技术出版社，2022
2，编著：《Oligosaccharides of Chitin and Chitosan: Bio-manufacture and Applications》，Springer Nature, 2019
2, 主编：《膜分离技术在食品发酵工业中的应用》，中国纺织出版社，2011
出版教材：
1, 主编：《食品过程工程》，中国轻工业出版社，2020
2，主编：《食品工程原理》，中国纺织出版社，2013.9(2018.9再版)
联系方式：
办公室：必赢电子游戏官网研究生楼1003室
电话：021-64252410
通讯：上海市徐汇区梅陇路130号，邮编：200237
E-mail: zhaoliming@ecust.edu.cn